28.1.116 NoncompInhib

Function

y=\frac{V_{\text{max}}x}{(1+\frac{I_\text{c}}{K_\text{i}})(K_\text{m}+x)}

Brief Description

Noncompetitive inhibition model for single substrate and single inhibitor.

Sample Curve

NoncompInhib.png

Parameters

Number: 4

Names: Vmax, Km, Ki, Ic

Meanings: Vmax = Maximum enzyme velocity, Km = Michaelis-Menten constant, Ki = Inhibitor constant, Ic = Inhibitor concentration

Lower Bounds: Vmax > 0, Km > 0, Ki >0

Upper Bounds: none

Note that this function is usually used in global fit, Vmax, Km and Ki should be shared, and Ic be fixed for each dataset. The initial value of Ki can be the mean of Ic.

Derived Parameters

Script Access

nlf_NoncompInhib(x,Vmax,Km,Ki,Ic)

Function File

fitfunc\NoncompInhib.fdf

Category

Enzyme Kinetics