28.1.29 DoseResp

Function

y=A1+\frac{A2-A1}{1+10^{\left( Logx0-x\right) p}}

Brief Description

Dose-response curve with variable Hill slope given by parameter 'p'.

Sample Curve

CFF Image080.jpg

Parameters

Number: 4

Names: A1, A2, LOGx0, p

Meanings: A1 = bottom asymptote, A2 = top asymptote, LOGx0 = center, p = hill slope

LOGx0 = -5.0 (vary), p = 1.0 (vary)

Lower Bounds: none

Upper Bounds: none

Derived Parameters

The span: span=abs(A1-A2)

The concentration at 20% response: EC20=10^(LOGx0 + log(0.25)/p)

The concentration at half response: EC50=10^LOGx0

The concentration for 80% response: EC80=10^(LOGx0 + log(4)/p)

Script Access

nlf_response1(x,A1,A2,LOGx0,p)

Function File

FITFUNC\DRESP.FDF

Category

Growth/Sigmoidal, Pharmacology