LOWESS and LOESS smoothing options have been added to the Smooth tool.
Both methods are locally weighted scatterplot smoothing, the most significant advantage is that they capture the major trend of the data but will not be seriously influenced by the fluctuations of data in a small X range.
To use these methods, select Analysis: Signal Processing: Smooth from the Origin menu, when a worksheet or a graph is active.
And you can either use Points of Window to define the degree of smoothing. Curve will be smoother with bigger points of window, or you can check the Use Proportion of Span check box. Curves will be smoother with bigger span.